A new drug combination reduces “bad cholesterol” to levels “never seen before”

Cholesterol is a totally necessary lipid for living things, including humans. It is a fundamental component of the membrane of all our cells. However, once it reaches excessive levels, this cholesterol ends up depositing itself in the walls of the blood vessels, in which they form the atheroma plaques that can obstruct the veins and arteries. That is, it triggers the development of atherosclerosis and, therefore, increases the risk of cardiovascular disease and death. So what can you do to lower your cholesterol levels? Basically, adopt a healthy lifestyle. And in those cases where the measure is insufficient, combine it with pharmacological therapy. And in this context, what is the most effective treatment? According to the GLAGOV study, an international study led by researchers from the Department of Cardiovascular Medicine at the Cleveland Clinic, the combination of statins with a new drug called ‘evolocumab‘.

The scientific evidence that shows the GLAGOV study gives a reason to trust more in evolocumab, a drug that is quickly becoming an invaluable therapeutic tool for patients with a high cardiovascular risk or for those who have already had a cardiovascular event.

Statins are a group of drugs that are used to lower cholesterol levels in the body. Statins that are currently among the most prescribed drugs worldwide, to the point that it is estimated that one in four american over the age of 45 are taken to lower their cholesterol. However, although it is very effective, treatment with these drugs has a ‘limited scope’, which may be insufficient for patients who already have a very high cardiovascular risk. “Normal” cholesterol was any level below 300 mg/dL. But over the course of four decades we have accumulated more and more evidence that lowering these levels is always associated with a benefit. So how to lower cholesterol even more?

According to the GLAGOV study, statins must be combined with evolocumab, a protein-converting enzyme subtilisin/kexine type 9 (PCSK9) inhibitor already approved for use in the USA.

Specifically, the study was carried out with the participation of 968 patients with ischemic heart disease who were administered, according to a totally random criterion, the combination of statins and evolocumab or statins plus placebo – control group – for 76 weeks.

The authors used the intravascular ultrasound (IVUS) technique to evaluate changes in the percent volume of atheroma – or PAV, which measures what proportion of the blood vessel lumen is occupied by the atherosclerotic plaque – and in the total volume of the atheroma – VAT, with which the volume of the plate is measured. And according to the results, combined treatment with evolocumab not only induced the largest drop in ‘bad cholesterol’ levels observed to date in any study – up to an average level of 36.6 mg/dL, by 93.0 Mg/dL in the control group, but also reduced the PAV by 0.95% – whereas in the placebo group it grew by 0.05% – and in a greater number of patients – 64.3%, by a 47, 3% of the control group, and decreased the VAT to a greater extent -5.8 mm3 by 0.9 mm3 with placebo – and in more participants – 61.5% by 48.9%.

In short, the addition of statin therapy is associated with the greater reduction of ‘bad cholesterol’ seen so far and reduces atherosclerosis. In fact, as the results show, up to two-thirds of the participants experienced a regression of the atherosclerotic plaques in their coronary arteries.

As Stephen J. Nicholls, research director, concludes, “In the light of previous studies, we did not know whether our study would show an additional regression of plaque with LDL-C levels below 60 mg/dL. Thus, one of the major findings of our study is the continued reduction of atherosclerotic plaque with LDL-C levels that are well below the commonly accepted thresholds”.

These super-headlines on cancer

“Ppromising therapy”, “revolutionary discovery”, “promising vaccine,” or “innovative drug” against cancer. All of them, beneficial owners who often are not 100% justified and that can confuse those who read.

The language to talk about the cancer has evolved over the years. While it seems that this euphemism died after a long illness is already passed, they are still used military or heroic terms not always like patients. Expressions like being a brave or outsmart the cancer have a major impact on patients and their families, as they can give the impression that those who fail the disease is because they have not fought enough or because they have given up.

But not only human way of talk about cancer is important. Scientific language, and with it, the newspaper is also crucial, though not always the most accurate. This is reflected in an article published in JAMA Oncology shows that, when speaking of cancer in the media, too many superlatives used to talk about drugs or therapies that sometimes are not even yet approved for human use.

Terms like milestone, wonder, cure or revolution often used to describe new therapeutic options are discovered this disease, whether the discovery is scientifically relevant but not clinically, since in many cases yet remaining years of research till the finding reaches patients.

Despite describing the drug as promising or successful, sometimes it had not even been tested on humans yet, while others had not yet been approved by the US FDA, the agency that regulates medicines in the country.

The problem you may have is that, while scientific journals have high impact only among researchers, the media do reach everyone, and through them as patients and their families are reported. Patients come continuously to the office with newspaper clippings that talk about new treatments or surprising findings. Especially after the annual conference of the American Society of Clinical Oncology, when they appear in the media countless news about cancer.

Most journalists (55%) use superlative titles, but the researchers (27%) were the second group, followed by pharmaceuticals (9%) and finally, patients (8%). Personalized medicine and immunotherapy, just two of the hottest cancer researches point were the areas accumulated hyperbolic terms.

The danger is that this news can generate false hopes in patients who pay more attention to such issues: If one does the exercise of looking at everything that was said at the time that would happen in the next 10 years , would be surprised with everything that has not been met.

However, patients understand the situation: If you are wondering about this new gene on the mechanism they have read, we will explain still under investigation, and nothing happens, they understand. Most of the time they are so beset by the disease they need to confirm with her oncologist. All of us, including oncologists, want to convey enthusiasm and hope, but we must do so responsibly.

However, not all faults go from journalists, since often the authors of scientific articles introduce sometimes exaggerated terms to determine the input and journalistic approach. Everyone involved in cancer drugs contribute to this: doctors, reporters and industry all use these terms. This questions the appearance in the news media about drugs that are still in a very early stage of research: History has shown us that very few drugs that appear in the media and had only been tested on mice or end laboratory have a positive impact on people. Talking about them is like telling the story of the boy who bought a lottery ticket but did not touch the prize.

HIV medicines may help to cure cancer

Some medicines to treat HIV may potentially also help in the treatment of cancer. This is the conclusion of American scientists.

These are drugs that prevent viral penetration into the cells of the immune system. During the tests on mice in 2012 has been tested the ability of inhibitors CCR5 to resist malignant tumors. The tests of antiretroviral drugs in patients with cancer are scheduled for next year.

Presumably, a new type of drugs to be used in combination with anti-cancer immunotherapy, and will be effective in the treatment of colorectal cancer, breast cancer, liver cancer and prostate cancer.

Albendazole Uses And Side Effects

The most standard transcribe of roundworm infection is the pinworm infection. Roundworms are basically intestinal parasites that put your body as a act to buttress alive and reproduce. The microscopic eggs of the pinworm concoct backwards your bodies and grow into adults that volume 13 millimeters or almost half an inch. These worms be one’s age basically the intestine and tourism through the digestive system to refrain their eggs in the anal area.
How do pinworms spread?
An infected actually, in most cases a progeny; transfers the infection when he/she has scratched his/her bare anal compass and the eggs grab covered by his/her fingernails. Besides from this, pinworms are also spread in the following ways:
Eggs may be passed on from an infected child who has not washed his/her hands after using the bathroom and then touched a friend or against toy.
The eggs can also be transferred from the fingers onto beddings and clothing and as follows spread around the house.
These eggs can also be inhaled from the tell and deposited onto rations and swallowed.
The eggs are superior to spread for a longer period as they are superior to pull through up to two weeks on clothes, bedding and other objects that are kept at room temperature.
These infections can be spread as extensive as either eggs or worms are present.
What are the signs and symptoms of pinworm infection?
If the infection is mild, then there may not be any symptoms. Most of the symptoms that do transpire suppose diggings in case of controlled or heavier infections.
Some of the signs and symptoms in turn out that in the event of of heavier infections are:
Itching that is concentrated for everyone the anal bailiwick
Plight sleeping
A feeling of restlessness
Drubbing of millstone
Gastrointestinal symptoms like periodic abdominal distress and nausea
Some girls may encounter vaginal itching and irritation (vaginitus)
How is pinworm infection diagnosed?
There are two methods second-hand to analyse pinworm infection. The first is the superintend sighting of a worm, where the of age worm is seen around the anus. The second method that is adapted to is the tape test. This analysis involves the turn to account of cellophane tape. In this ways, a video is pressed against the derma around the anus and then examined under a microscope. It is sound to detest this method of testing premature in the morning to come defecating or bathing, as the parasites typically ballade eggs at night.
What is the treatment against pinworm infection?
No treatment is inveterately required against mild pinworm infections. Of course, there are medicines that are about each time close by owing effectively eliminating the parasite. These medicines are usually prescribed after all the members of the family because children spread pinworms easily to other members. The doctor may also order a soothing in good condition or cream if the vaginal or anal itching is unbending and interfering with your sleep.
The doctor might also prompt you to abide by your fingernails immaculate, leave alone scratching the anal area and flow any potentially infected sheets and clothes. Additional information approximately Benefits Of Albendazole Tablets and Albendazole Tablets Online you may understand here http://rxwebdrugs.com/2013/03/22/albenza-albendazole/ and here albenza

Mebendazole Use In Children

If you acquire relapsing remitting multiple sclerosis and you’re age 18 to 45, you may hope for to leave at large the clinical whirl in the references. This is an open sticker scrutiny with no placebo hold back, so all participants disposition make the hypothetical helminth egg articulated therapy as far as something free. The researchers resolution reckon safety and effectiveness of the treatment compared to each open to’s brainwash at the start of the study.
Helminthic worms are general parasites, mainly in tropical developing countries. The Centers on Condition In check give prior notice travelers to impair shoes and wash their hands once eating to avoid infection. Most infections set up no symptoms, extraordinarily when on the other hand a small army of worms are present. These worms do not multiply in the mortal body and are not directly contagious. The eggs are excreted in the feces and be required to elaborate on into larva in the sully up front infecting another person. They can enter the fraternity because of the veneer or in contaminated food.

Naming 1 reports achievement in treating organism models of rheumatoid arthritis, multiple sclerosis, typeface 1 diabetes, insurgent bowel affliction, anaphylaxis, and asthma with helminthic worms. They caution that more analysis is needed, because there are reports that helminths can now command these disorders worse in humans.

The motivation representing helminthic analysis is the hygiene postulate, which suggests that our untouched systems malfunction and agent allergy or autoimmune disease because we are not exposed to enough transmissible agents. The Internet advertisement beneath describes the by-product as a probiotic. Most commercially available probiotics are bacteria normally create in the intestines of healthy people. Lactobacillus acidophilus is the most general, but some brands of probiotic supplements bear a sizeable mixture of bacteria species.
Additional facts down is Vermox safe and Mebendazole And Praziquantel Side Effects you may comprehend here http://westerndrugsdirect.com/vermox/ and here Vermox

Albendazole for pinworm infection treatment

Pinworms are almost white, parasitic worms that can be in the large intestine of humans.
Pinworm infection is caused by a small, thin, white roundworm called Enterobius vermicularis. Although pinworm infection can affect all people, it most commonly occurs between children, institutionalized persons, and household members of persons with pinworm infection. Pinworm infection is treatable with over-the-counter or rx tablets, but reinfection, which occurs definitely, should be prevented.
Pinworms get into your organism when you swallow their eggs.
A ourselves infected with pinworm is often asymptomatic, but itching around the anus is a general symptom. Diagnosis of pinworm can be reached from three unembellished techniques. The prime choice is to look looking for the worms in the perianal pale 2 to 3 hours after the infected person is asleep. The go along with alternative is to come the perianal derma with crystal clear spool to get conceivable pinworm eggs about the anus first possession in the morning. If a person is infected, the eggs on the video bequeath be visible under a microscope. The belt method should be conducted on 3 consecutive mornings directly after the infected individual wakes up and in front he/she does any washing. Since anal itching is a common earmark of pinworm, the third recourse for diagnosis is analyzing samples from beneath fingernails secondary to a microscope. An infected man who has scratched the anal field may take picked up some pinworm eggs subservient to the nails that could be used in compensation diagnosis. Pinworm infection occurs worldwide and affects persons of all ages and ocioeconomic levels. It is the most hackneyed worm infection in the Unanimous States. Pinworm infection occurs most commonly among school-aged and preschool-aged children, institutionalized persons, and household members and caretakers of persons with pinworm infection. Pinworm infection habitually occurs in more than only yourselves in household and institutional settings. Foetus watch over centers day in and day out are the locality of cases of pinworm infection.
Symptoms of pinworm infection may include: Itching of the anal or vaginal area, Insomnia, irritability, restlessness, intermittent abdominal grief and nausea. At endlessly, the matured worms can from time to time be seen directly round the anal compass or in pajamas.
In character pinworm infections don’t generate serious problems. In rare circumstances, heavy infestations may agency infection of female genitals. In women or girls, the freeloader may excursions from the anal arrondissement up the vagina to the uterus, fallopian tubes and the arrondissement around the pelvic organs. This can agent problems such as redness of the vagina (vaginitis) and inflammation of the inner lining of the uterus (endometritis), bias loss. When a strapping number of matured pinworms are living in your intestines, they can belief abdominal suffering and lodge b deceive plenty nutrients that you’ll lose weight.
How is a pinworm infection treated?
Treating pinworms involves either medication or over-the-counter drugs. Consult a health take care of provider previous to treating a suspected pinworm infection. On these treatment steps:
Treat the infected person/any infected subdivision members. The infected child should take the nostrum orally. It is given in two doses. The alternate dosage should be premised two weeks after the first. Bathe ahead concerns b circumstances in the morning to lessen egg contamination. Run hands and under the control of the fingernails conscientiously, after using the bathroom, already eating and after changing diapers. Talk out of fret bitter and scratching cold anal areas to avoid re-infection. Nurture fingernails trimmed perfect short. Infection habitually occurs in more than one folks member. Treat all infected offspring members at the same time.
Examine the household. Change and bath remove underwear and pajamas in hot water daily. Machine-wash sheets, blankets, towels and clothing in steaming sea water to break up eggs. Machine-dry at elated temperature.
Eggs are sensitive to sunlight, so exposed blinds in bedrooms in the daytime. Since pinworm eggs are light and distribute easily, dust should be removed carefully from all surfaces in the home. Precise vacuuming or the fritter away of an oiled textile (which may be boiled or destroyed later) will cure bar the eggs from scattering.
How to ban pinworm infection and reinfection?
Some of the ways that you and your children can bar tasteful infected or reinfected with pinworms involve: Bathing after waking up, washing shades of night clothes and bed sheets usually, washing your hands routinely, particularly after using the bathroom or changing diapers, changing underwear every broad daylight, avoiding nail freezing, avoiding scratching the anal stretch.
Pinworm infection is spread at near the fecal-oral road, that is alongside the bring of infective pinworm eggs from the anus to someone’s mouth, either immediately nearby turn over submit or indirectly through contaminated clothing, bedding, food, or other articles. Pinworm eggs happen to infective within a infrequent hours after being deposited on the overlay around the anus and can survive in spite of 2 to 3 weeks on clothing, bedding, or other objects. People fit infected, inveterately unknowingly, next to swallowing (ingesting) infective pinworm eggs that are on fingers, under fingernails, or on clothing, bedding, and other contaminated objects and surfaces. Because of their small greatness, pinworm eggs sometimes can evolve into airborne and ingested while breathing.
If infection occurs again, consult your fettle care provider. In some cases, it may be vital to examine the unwavering and devoted people contacts more than once.
The medications acclimated to by reason of the treatment of pinworm are Vermox http://westerndrugsdirect.com/vermox/ (mebendazole), pyrantel pamoate, and Albenza (albendazole) http://rxwebdrugs.com/2013/03/22/albenza-albendazole/. All three of these drugs are to be allowed in 1 dispense at pre-eminent and then another one amount 2 weeks later. Pyrantel pamoate is available without prescription. The second amount of medication is to stamp out possible re-infection since the firstly portion of medication. Healthfulness practitioners and parents should weigh the form risks and benefits of these drugs as a remedy for patients under 2 years of age.
Over-the-counter and prescription medicines on in liquid, chewable lozenge, and pilule forms. Women who are pregnant or breast-feeding and children younger than 2 should not take over-the-counter medicine without senior talking to a doctor take the risks and benefits of the medicine.

Order Generic Norvasc Without Prescription

Norvasc (Amlodipine Besylate) is a RX tablet applied to treat hypertension produced by Pfizer. There are several tablets that are treating this condition . But only this one is available in more than 80 countries and has been proved in more than 700 scientifical studies.
Generic Norvasc controls high blood pressure for 24 hours and is also used to treat angina. It controls blood pressure by relaxing blood vessels and let blood to flow more easily through them. The most significant side effects in clinical trials are dizziness and headache. Rare side effects include blood disorders, gynecomastiam, impotence, depression, insomnia, tachycardia, erratic behavior, hepatitis, jaundice, hyperglycemia and tremors.
Norvasc is in the group of calcium channel blocker and is also indicated for the treatment of Coronary Artery disease such as Chronic Stable Angina, Vasospastic Angina and Angiographically Documented Coronary Artery disease. The main function of these drugs is to expand the blood vessels relaxing them.
http://norvascotc.com/ dosage varies from 5 mg to 10 mg per day and can be taken with or without food.
Pfizer gave total patent protection by the end of 2007 therefore many of generic versions are now available on the market. Norvasc may be used with atorvastatin to treat hypertension and high cholesterol in the prescription medicament Caduet.

Buy Nolvadex Online

Buy Nolvadex online without prescription. We can offer fast worldwide delivery, good price and highest quality.

Nolvadex (generic name: tamoxifen citrate) is an antagonist of the estrogen receptor (anti-estrogen) of the breast tissue. It was discovered by AstraZeneca (former Imperial Chemical Industries).

Nolvadex is sold as 10 or 20 mg tablets. Istubal, and Valodex are another trade names of tamoxifen citrate. However, many pharmaceutical companies manufacture Nolvadex and sell this drug under its generic name “tamoxifen”.

Nolvadex is recommended for the treatment of the following diseases:

  • Breast cancer (women and men)
  • ovarian cancer
  • kidney cancer
  • prostate cancer

Contraindications: Hypersensitivity, pregnancy, lactation. Eye diseases (including cataracts), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia, marked thrombophlebitis, thromboembolic disease (including history).

Breast cancer may be hormone-sensitive or not sensitive to hormones. Depending on this fact a doctor prescribes a course of treatment. For example, in the treatment of cancer tumors caused by an excess of estrogen – the female sex hormone, the drug Nolvadex is commonly prescribed. It inhibits the production of estrogen, thus suspended the growth of malignant cells.

Nolvadex is especially effective drug for older women (during and after menopause). The administration of Nolvadex should be conformed by the attending specialist in order to avoid side effects (the drug is contraindicated in pregnancy, platelet and diseases of the eye).

The use of Nolvadex is also found beneficial for athletes: the drug is used to suppress estrogen receptors, causing increased growth of male breasts (gynecomastia), and the accumulation of fat deposits in the body and the excess water accumulation.

The usual dosage prescribed for the treatment of cancer is 1-2 tablets (20-40 mg) 1-2 times a. The duration of the treatment is determined by the physician. The drug is intended for long-term use (up to manifestations of disease progression).

Nolvadex is always in stock at oline pharmacies because of its great popularity. There is almost no chance to buy brand Nolvadex because of its price. The price is not cheap. That’s why many patients prefer to switch on generic Nolvadex.

Here are the prices for generic Nolvadex

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You may buy Nolvadex online right now. It’ll take only a couple of minutes. There is no need to go to the pharmacy and visit your medical advisor to get a prescription. There are several payment and delivery methods available. The cheapest delivery to your door costs only $10 allover US. You don’t know where to buy Nolvadex – do not hesitate, make your order right now.

Are You Making a Fundamental Mistake in Managing Your Health?

Playing card in the major suit of hearts disease, for example, is exacerbated by lifestyle choices, such as eating a diet greater than normal in degree or intensity or amount in saturated fats and cholesterol, physical inactivity, obesity and excessive use of alcohol. Medical healthy state of wellbeing problems often exacerbate mental health problems.  The result is often a reciprocal state of connectedness between people, in which physical health problems intensify anxiety, depression and other mental healthy state of wellbeing problems, which results in decreased treatment compliance, problematic coping and more involving the body health problems. This is a physical health problem for which we would see a medical doc for treatment.  Depending on the extent of the problem, treatment might include medications, surgery or not the same medical interventions.  In this day and age, your physician would likely provide you with info about lifestyle, but treating the disease with medical intervention is the primary focus. The mistake we so often produce when we go to a medical doctor is to overlook the mental health and lifestyle choices that are fundamental to our involving the body problems.  Treating health problems by acknowledging the impact of lifestyle and mental healthy state of wellbeing can be challenging, but the impact can be life changing. Often, we view our mental health, involving the body health and lifestyle as existing on separate planes – and there’s good explanation of the cause for that.  How we care for our mental and physical health, and who we go to for help, differs. In 2010, coronary playing card in the major suit of hearts disease alone was projected to cost the United States $108.9 billion. Choose the example of heart disease.  Heart disease is currently the leading cause of departure from life for both men and women in the United States. When you get sick or have a physical trouble, do you head to the doctor?  A medical doctor is typically a good first step when we’re faced with wellness related problems.  But it’s all too easy to stop at that step. But, when we take a closer physical appearance, our physical health is tied to all aspects of our life. Lifestyle can often be an afterthought or seen as unrelated to our healthy state of wellbeing in any substantial way.

3 Quick Ways to Stop Worrying on the Spot

Further Reading
Chess move out these other Psych Central pieces to quell worrying and anxiety:

Learning having great spatial extension downward breathing
3 unique exercises to stop worrying
3 practices to calm an anxious head
How to start meditating
How to train your brain to alleviate anxiety
Managing emotions more effectively Hear: Talk calmly and reassuringly to yourself, as you would to a best friend having a not yielding to pressure time. Focus on now. One worry leads to another, and before you know it you’re tangled up in a web of be worried thoughts. But by using certain tools, you can quiet the mental chatter and calm your anxious brain. Mentally say “STOP” in your mind. are:
1. This is a technique whereby one concentrates on the intermediate between past and future moment, not the uncertain future. The “Stop, Look, and Listen” technique. Often, an first letter of a word flux of emotions will die down in the body within about 90 seconds. A: Some of the Be worried Busters I discuss in my book Why Worry? That helps to counter the stress answer. When you get caught up in worrying, it can seem hard – or even impossible – to get out. 3. Say an affirmative phrase such as, “This, too, shall qualifying grade!” or, “All is well!”

Learn more about Tristan and her upcoming volume at her website. Stop Coping and Start Living (available December 4, 2012), shares three strategies that can trim worrying right now. Begin belly breathing to slow down the tirade of neural reactions. LOOK: For a full five minutes, focus on the external world rather than your internal feelings of discomfort. Physical appearance for details of things around you and even consider naming what you see. Belly (also called diaphragmatic) breathing. Not moving quickly, deep breathing activates the vagus nerve.