Average or ordinary or usual adverse reactions included nausea, dry mouth, constipation, decreased appetite, and sleepiness.Cymbalta also is approved to special pleasurable occurrence major depressive disorder and generalized anxiety disorder, and a form of nerve physical pain in diabetics, all in adults 18 and older.The pain is gone. It took around 3 1/2 weeks to ‘sudden stimulation in’ fully. I can play with my kids again. Cymbalta worked for my fibromyalgia physical pain when nothing else would.I share the same experiences as other reviewers. Eli Lilly said Monday that its antidepressant Cymbalta (duloxetine) has been approved by the U.S. It’s a priceless medical profession. I started taking Cymbalta one year ago and it has been a life changing event. In plus to affecting mood, it’s believed these substances are part of the body’s natural physical pain-surpressing system, Lilly said.In a pair of three-month trials involving 874 people with fibromyalgia, Cymbalta significantly reduced physical pain levels, compared with a non-medicinal placebo, the company said. Most days are great. While its causal agent is unknown and there is no known cure, it’s believed it may be related to a combination of changes in encephalon and spinal cord chemistry, genetic factors, and stress, the company said in a financial statement.Cymbalta affects production of two naturally occurring brain substances, serotonin and norepinephrine. No demand to tell anyone the impact it has on my life. It allowed me to get off the two opiate pain medications I was on. Fibromyalgia was finally diagnosed 10 years ago.