It did cut down sexual performance and cause difficulty with orgasm, but it was worth it. I was thrown into a untamed episode of mania within 3 weeks of taking a 60 mg dose of Cymbalta. After 10 months I got off of it and everything returned but the physical pain.Cymbalta provided amazing relief for my neuropathic pain and depression though it also seemed to have got bad side effects. Food and Drug Administration to treat chronic musculoskeletal physical pain, stemming from conditions including lower back pain and osteoarthritis.Since its blessing as an antidepressant in 2004, some 30 million people in the United States have got used the drug, the agency said in a news release. More serious adverse reactions have got included liver damage, allergic reaction, pneumonia, depressed mood, and suicidal thoughts and conduct, the agency said.This drug is fantastic. I tolerated it well and had few side effects, dry oral cavity and a little wired for the first week on it but that was it. I would advise a cautious draw close. was originally prescribed Cymbalta for relief of pain caused by neuropathy in my leg. I had neuropathic physical pain and depression, due to the chronic pain, for over six months. I have bipolar disorder. I tried NSAIDS and not the same drugs which did little, if anything. I had taken this medication for over a twelvemonth and after choosing to discontinue it, the withdrawal symptoms that followed seemed severe. Cymbalta (duloxetine hydrochloride) has received expanded blessing from the U.S. The FDA also has sanctioned Cymbalta for diabetic pain, generalized anxiety mess and fibromyalgia.The most common side effects from Cymbalta use include nausea, dry oral cavity, insomnia, drowsiness, constipation, fatigue, and dizziness. Bipolar patients should monitor themselves for symptoms of mania while taking Cymbalta.